Destroy Brain Fog and Increase BDNF: The Ultimate Guide - Dope.Fresh.Fit.

Destroy Brain Fog and Increase BDNF: The Ultimate Guide

Brain Supplements

Jun 09
brain fog supplements

Increase BDNF to level up your brain.

Brain-derived neurotrophic factor, or BDNF for short, is a protein that plays a critical role in neurogenesis: the creation of new neurons.

BDNF protects existing synaptic connections while making the brain more adaptive to stress.

It’s “Miracle-Gro for your brain,” according to Harvard Neuropsychiatrist John J. Ratey, MD, who looks in detail at BDNF’s connection to exercise in his book: Spark, The Revolutionary New Science of Exercise and the Brain.


  • Protects and repairs brain cells(R)
  • Encourages the growth of new brain cells.
  • Improves mood, memory, and learning.
  • Treats depression and anxiety.

According to Ratey, BDNF is a “crucial biological link between thoughts, emotion, and movement,” and that exercise is one of the fastest ways to increase BDNF and form new connections in the brain.

What is BDNF?

Not very long ago, the general scientific opinion was that your brain was in a state of gradual and constant deterioration from the time it fully matured in your early 20s until your death.

Today we know that the brain is plastic, meaning it grows and adapts throughout your life.

Everything you do and everything that you put in your body has some influence on the development of neurons in the brain.

increase bdnf supercharge your brain

In the last decade have huge strides been made in BDNF research.

Since its purification in 1982, researchers have become more focused on BDNF for the central role it plays in brain development and pathology.

BDNF is one of several proteins in the neurotrophin family, which manage the development of new nerve cells as well as the maintenance of mature ones.

Think of BDNF as the gardener and groundskeeper of your brain. BDNF manages apoptosis, or cell death, and 'prunes' neurons to prevent cell mutation and the development of disease.

BDNF is found in varying levels throughout the brain and body including in your blood serum, cerebral spinal fluid (CSF), and areas of the brain like the hippocampus and neocortex. (R)

Quick Facts About BDNF

Research implicates BDNF in a host of neuronal functions, including neurogenesis, or the growth and development of neuronal tissue.

New evidence suggests that BDNF has a supporting role in learning and memory through the modulation of cellular metabolism.

Recent research indicates that the expression of BDNF may even underlie biological processes related to the inheritance of cognitive traits. (R)

BDNF is implicated with memory, learning, sleep, appetite, and neuronal survival. The right diet habits can clear brain fog by increasing BDNF.

Studies involving developing embryos of rodents show that to increase BDNF stimulates the growth of dendrites and increases the density of cortical neurons in the spine.

Research shows that BDNF regulates the development of neural circuits that influence a range of psychiatric and mood disorders, including depression. 

Post-mortem analysis of human subjects suffering from depression at the time of their death displayed decreased levels BDNF in the prefrontal cortex.

Many stress-induced mental disorders that are impacted by lower levels of BDNF that is itself triggered by raised levels of stress hormones.

Elevated levels of stress hormones can cause lower levels of BDNF and in turn exacerbate stress-induced mental disorders.

Animal studies show that BDNF can cause damaged cells to regenerate, an encouraging phenomenon that has potential applications in the treatment of many devastating neurodegenerative brain diseases, including Huntington's disease, Lou Gehrig's, Alzheimer's, and Parkinson's.

There may even be a connection between increased BDNF and insomnia, which occurs at much higher rates among depressed patients, although more research needs to be done in this area.

Exposure to stress inhibits the expression of BDNF in the prefrontal cortex as well as other areas of the brain.

BDNF in the peripheral nervous system is stored in blood platelets where it's stored until you need it. (R)

The Chain of Mental Health

chain of mental health diagram

Increase BDNF with Healthy Habits

BDNF and Social Life

Studies show that people who have socially enriched lives have higher levels of BDNF.

We're social creatures.

A social life full of intimacy and variety gives your brain with the inspiration it needs to form new synaptic connections and improve learning.

The mental stimulation that comes with a vibrant social life increases BDNF expression.

Early and frequent socialization continues to have a positive effect on test subjects even into adulthood.

In rodent subjects, a stimulating social environment is associated with increased neurotrophin levels in the hippocampus and hypothalamus. (R)

BDNF and Romance

New research indicates that BDNF is involved in romantic attachment, but, interestingly enough, only in female test subjects. Researchers hypothesize that estrogen increases BDNF expression in several areas of the brain. (R)

Oxytocin and vasopressin have long been associated with romantic relationships, but BDNF may now need to be added to the list.

BDNF and Sleep

Sleep deprived individuals tend to have low levels of BDNF.

Quality sleep is essential to brain health, and poor sleep can be detrimental to focus and memory.

Shoot for at least 7 hours of uninterrupted sleep each night. If you're having a hard time falling asleep and staying asleep, try eating 1-2 tablepoons of raw honey before heading to bed.

Regular exercise can protect against some of the negative effects that poor sleep has on BDNF expression.

The more sleep-deprived you are, the more you need slow wave sleep to rest and restore. BDNF is the signal molecule that increases slow wave sleep. (R)

BDNF and Circadian Rhythm

BDNF has a rhythm that works in conjunction with your sleep cycle.

You have the most BDNF when you wake up in the morning, and then BDNF levels decrease throughout the day.

When light hits your retina for the first time after waking up, the neurotransmitter glutamate is activated in the hypothalamus, which then triggers BDNF expression.

Evidence indicates that low levels of BDNF could be disruptive to the sleep cycle. (R)

BDNF and Sunlight

Exposure to sunlight for as little as 10-20 minutes a day can increase BDNF levels in the brain.

A recent study involving 2,851 individuals found that BDNF levels increased considerably in the spring and summer, and decreased significantly in the fall and winter, and was determined to be correlated to the number of hours participants spent exposed to sunlight. (R)

The study was directed by Dr. Marc Molendijk at Leiden University in the Netherlands.

BDNF and Stress

Lowering stress increases BDNF, and few activities are proven to be more effective at reducing stress than meditation and yoga.

Flotation therapy also has a growing body of research that supports its effectiveness in reducing stress. 

Stress reduces the expression of BDNF because stress of hormones like cortisol interfere with BDNF production. 

In a recent study published in the Frontiers of Neuroscience, thirty-eight participants were tested for BDNF and inflammation before and after a 3-month yoga and meditation retreat.

By the end of the retreat, participants had reduced anxiety, lower levels of inflammation, and increased levels of BDNF. (R)

Supplementing with the amino acid theanine is scientifically proven to raise BDNF and reduce symptoms of anxiety.

BDNF and Exercise

During intense physical activity, the brain and body work in overdrive to process information and adapt to the stress, making new connections between neighboring cells.

Although BDNF levels stay raised for several minutes after an intense workout, it’s important to think of BDNF production in the long term.

What Type of Exercise is Best for BDNF?

The most efficient way to raise levels of BDNF is with exercise.

According to research, sustained cardiovascular workouts and high-intensity exercise for at least 30 mins is best for increasing BDNF.

The downside to high-intensity interval training is that, if you're not used to hard workouts, it could trigger stress hormone production.

Whenever stress hormone levels are raised BDNF expression decreases and cancels out any BDNF-promoting benefits.

Encouraging new reports indicate that even low-intensity exercise  can increase the expression of BDNF. (R)

Exercise and the Brain 

Exercise improves memory in stroke patient's as well as healthy adults.

In a study done on rodents with brain ischemia, moderate to low-intensity exercise was best for improving the spatial memory performance of test subjects. 

High-intensity exercise test groups had high levels of corticosterone, which was used as a marker for stress response.

The high-intensity groups also tested for lower levels of serum BDNF. Low and medium intensity groups had both higher levels of BDNF and lower levels of corticosterone. (R)

Exercise enlarges the hippocampus, the area of the brain where a large percentage of BDNF production takes place.

As we get older, the hippocampus shrinks, and we're at greater risk for memory impairment and dementia.

Physically fit adults have larger hippocampal lobes.

In a test involving 120 older adults, aerobic exercise increased the size the anterior hippocampus, which also led to an improvement in spatial memory performance

Individuals that displayed an increased in hippocampal volume also tested for increased BDNF in blood serum. (R)

With a consistent exercise routine, your brain will be on point and ready to face the challenges that get thrown your way. 

I definitely feel less stress and lower anxiety when I exercise at the beginning of the day. If I need some extra help staying calm during a high-stress day I also take GABA supplements or passionflower extract. Passionflower acts on GABA, a neurotransmitter that's critical for reducing anxiety. 

BDNF and Weight

There's a convincing body of evidence connecting obesity and high body fat percentage to lower levels of BDNF.

Losing fat, something that the ketogenic diet and intermittent fasting do wonders for, can help increase BDNF expression.

Recent studies indicate that BDNF as critical to regulating energy metabolism and controlling body weight.

Obesity has neurodegenerative risk factors in addition to its more well-known cardiovascular complications.

Dementia is more common in obese patients, as is decreased hippocampal volume, a common indicator of pathological brain aging.

The connection between low BDNF and obesity has been documented in a study of Japanese children. (R)

BDNF and Digestive Health

The bacteria in your gut impacts brain function through the expression of BDNF.

Studies conducted with both rodents and human test subjects indicate that the bacterial strains Bifidobacteria and Lactobacilli are especially influential to BDNF production.

Administration of probiotics (beneficial bacteria supplements) and prebiotics (food for the bacteria) increased the expression of BDNF in the brain. 

Dense and fibrous food that's low-acidity is great for your digestive tract. It lowers inflammation and provides the fuel that healthy gut bacteria needs to thrive. Supplementing with the amino acid glutamine is critical if you have digestive health issues. Gutamine is the most abundant amino acid in the body and is essential to repairing the lining of the gut.

BDNF and Sugar

In rodent tests, a diet that's high in refined sugar reduces the expression of BDNF in the hippocampal region of the brain and negatively impacts neuronal plasticity and learning. (R)

BDNF and The Ketogenic Diet

The ketogenic diet is a high-fat, low-carb diet that triggers the body to run on ketones, or fat cells, as its primary fuel source.

When you're running on fat, you're in ketosis. Ketosis-supporting supplements like MCT oil and exogenous ketones oil for fast-acting, slow-burning energy.

The best way to get into ketosis is either by eating very little throughout the day or by intermittent fasting.

Ketosis has many clinically proven neuroprotective properties, including increased BDNF, enhanced GABAergic neuro-transmission, improved mitochondrial function, and reduced neuro-inflammation (This is just a fancy way of saying that your brain operates more smoothly and is less inflamed). (R) 

Avoiding sugar is also part of the ketogenic diet.

Intermittent fasting leads to a bigger increase in ketone levels than restricted eating alone. 

If you're in the mood for quick 600-word read about how to increase BDNF and clear brain fog with diet, click here. You can always return later and use this article as an epic resource.

Health Benefits of the Ketogenic Diet

  • Weightloss
  • Improved physical endurance
  • Improved focus
  • Lower blood pressure
Reduced Seizure Activity

The ketogenic diet is well recognized for its ability to reduce seizure activity due to its neuroprotective effects.  

Treating Neurodegenerative Disease

Ketosis improves the cognitive function of patients with various neurodegenerative diseases.

After one month on the ketogenic diet, test subjects with Parkinson's disease improved their scores on the Unified Parkinson's Disease Rating Scale by a mean of 43%.

The ketogenic diet also reduces symptoms in Alzheimer's patients, and early data suggests that the ketogenic diet could be beneficial to children with autism. (R)

BDNF and Intermittent Fasting

Intermittent fasting enhances brain health by improving your metabolism.

Periods of caloric restriction (aka not eating) increase BDNF production. (R)

Before you run in fear of the word “fasting,” let’s define it in regards to BDNF production.

To experience the benefits of intermittent fasting you only have to last 12-24 hours without food.

That means that if you go to bed at 9 pm and wake up at 6 am, you'll only have to wait 3 hours before having your first meal.

Supplements to Increase BDNF

Omega 3 Fatty Acids (Fish Oil)

The essential fatty acids EPA and DHA increase BDNF levels in the brain.

Fish oil is one of the brain fog supplements that I never go long without. 

The omega-3 fatty acids in fish oil soothes inflammation.

DHA helps regulate gene expression and protects neurons from death.

Fish oil and krill oil are the best sources of these important nutrients.

Other sources include nuts and seeds, vegetables and some fruit, and egg yolk, poultry, and meat,

In rat studies, krill oil supplementation enhanced cognitive function and displayed anti-depressant effects.

Similar anti-depressant effects have been noted in human trials.

Studies also indicate that DHA normalizes brain activity in subjects recovering from traumatic brain injury.

Omega 3s reduce oxidative damage, promote brain development, and help regulate mood disorders. (R)

My favorite fish oil.

Turmeric (Curcuma longa/Curcumin)

Used in traditional Chinese medicine for thousands of years, turmeric (Curcuma longa) has anti-inflammatory properties that aid in cell repair, liver function, gut health, and chronic stress reduction. (R)

Curcumin is the active anti-inflammatory component of turmeric that studies now show has anti-depressant effects.

Curcumin increases BDNF expression in the hippocampus and frontal cortex.

Turmeric extract, out of all the brain fog supplements, that's always in my supplement stack. 

Studies also indicate curcumin’s effectiveness at improving learning and memory deficits

I rotate it out every few months like I do with all my supplements, but I'd say that 8-9 months out of the year I take it regularly.  

My favorite curcumin extract.


Zinc is an essential trace element that plays a vital role in regulating cell proliferation, apoptosis (cell death) and DNA repair mechanisms.

I take zinc regularly, especially leading into the cold and flu season.

Zinc strengthens the immune system.

Zinc is an effective antioxidant and anti-inflammatory.

Researchers estimate that approximately 2 billion people in the developing world are zinc deficient.

Zinc deficiency impairs brain function in animal studies. (R)

Zinc is one of the most important brain fog supplements I take.

It's also critical for testosterone support and sex drive. 

When your zinc levels drop, so does testosterone production.

Zinc is also important in the fight against depression

My favorite zinc supplement.


In a recent clinical study, elevated levels of magnesium in the brain resulted in improved learning and memory. 

For me, magnesium is a brain fog supplements that helps me think more clearly and reduces anxiety.​​

Further evidence suggests that magnesium treatment increases the effectiveness of cognitive therapy for anxiety, phobias, and PTSD

The study suggests that increased levels of magnesium increase synaptic plasticity in the hippocampus.

My favorite magnesium supplement.


Resveratrol is a polyphenol compound that has antioxidant properties and anti-carcinogenic effects.

It reduces hippocampal atrophy in cases of chronic fatigue.

Reseveratrol is a brain fog supplement that's found in red wine as well as several other plants.

Resveratrol has neuroprotective effects and encourages the expression of BDNF. (R)

My favorite resveratrol supplement.


L-theanine, also known as theanine, is an amino acid found in green tea leaves. 

Theanine is one of the brain fog supplements that reduces anxiety while improving brain function. 

I take theanine supplements regularly. They calm me down similar to how magnesium does. 

Theanine is essential to GABA produciton. 

Theanine reduces anxiety and improves cognitive function by increase GABA in the brain.

My favorite theanine supplement.

NAC (N-acetylcysteine)

NAC (N-acetylcysteine) is a critical nutrient that's made in the body from the amino acid L-cysteine. 

Brain fog supplements like NAC improve overall brain function while treating a variety of mental health disorders. 

The body uses NAC to make glutathione. 

Glutathione is a potent and versatile antioxidant and anti-inflammatory. 

I continue to take NAC roughly 8 months out of the year. 

My favorite NAC supplement.


Brain fog supplements like ashwagandha heal the brain by normalizing the stress response. 

When you're chronically stressed, the adrenal gland produces too much cortisol. 

While it's producing cortisol, the body stops producing other essential hormones. 

This can lead to chronic fatigue and low sex drive. 

I take ashwagandha nearly everyday. 

I'm not sure what the research says on this, but I used to get really jittery when I'd drink coffee. Since I started taking ashwagandha extract, I can drink a couple cups of coffee a day without any problem. 

My favorite ashwagandha supplement.

Other Foods, Herbs, Supplements, and Drugs

  • Dark chocolate 
  • Flavonoid-rich food
  • Green tea
  • Pu-erh tea
  • Prebiotics 
  • Ginseng
  • Bocopa monieri 
  • Coffee Fruit Extract
  • Butyrate
  • Biacalin
  • Melatonin 
  • DHEA
  • Ashwagandha
  • Niacin


Our brains and bodies thrive on variety.

Exposure to sunlight, proper nutrition, exercise, restful sleep, and a rich social life together till the soil for your growing mind.

The seed...BDNF.

Encouraging the expression of this critical hormone can lead to a healthier, happier life.

Increasing BDNF might even make you feel like a super hero.

Wear a cape at your discretion 😉


None of the statements or suggestions in this article have been evaluated by the Food and Drug Administration. Always consult with your doctor before acting on the advice prescribed at Dope.Fresh.Fit.